Anatomy and Physiology: Practice Test

A and P II Chapter 24 practice test 1. Which of the following digestive regions is responsible for the propulsion of materials into the esophagus? Answer: pharynx 2. The active process that occurs when materials enter the digestive tract via the mouth is: Answer: ingestion 3. Sympathetic stimulation of the muscularis externa promotes: Answer: muscular inhibition and relaxation 4. Which of the following statements about peritonitis is false? Answer: It leads to inflammation of the digestive mucosa. 5. Which of the following major layers of the digestive tract is described as a layer of dense irregular connective tissue filled with blood vessels and the plexus of Meissner? Answer: submucosa 6. Strong contractions of the ascending and transverse colon moving the contents of the colon toward the sigmoid colon are called: Answer: mass peristalsis 7. Which of the following salivary glands produce salivary amylase, a carbohydrate-digesting enzyme? Answer: 1. parotid glands 2. sublingual glands 8. Which of the following is not a function of saliva? Answer: initial digestion of proteins 9. The three pairs of salivary glands that secrete into the oral cavity include: Answer: parotid, sublingual, and submandibular 10. Crushing, mashing, and grinding of food are best accomplished by the action of the: Answer: bicuspids 11. The three phases of deglutition are: Answer: buccal, pharyngeal, and esophageal 12. On its way to the esophagus, food normally passes through the: Answer: oropharynx and laryngopharynx 13. The pharyngeal muscles that push the food bolus toward the esophagus are the: Answer: pharyngeal constrictor muscles 14. Solid food and liquids are carried from the pharyngeal region to the stomach by the: Answer: laryngopharynx 15. The inferior end of the esophagus normally remains in a state of active contraction that: Answer: prevents the backflow of materials from the stomach into the esophagus 16. The contractions of the stomach are inhibited by: Answer: secretin 17. Which of the following is secreted by the stomach? Answer: gastrin 18. The division of the small intestine that contains the Brunner glands is the: Answer: duodenum 19. An enzyme not found in pancreatic juice is: Answer: disaccharidase 20. Bile entering the gallbladder must pass through the: Answer: cystic duct 21. The hormone that promotes the flow of bile and of pancreatic juice containing enzymes is: Answer: cholecystokinin 22. The longitudinal ribbon of smooth muscle visible on the outer surfaces of the colon just beneath the serosa are the: Answer: taenia coli 23. The vermiform appendix is dominated by what type of lymphatic structures in the mucosa and submucosa? Answer: lymphoid nodules 24. The vitamins liberated by bacterial action and absorbed in the large intestine are: Answer: biotin, pantothenic acid, and vitamin K 25. Which of the following organic nutrients are not absorbed by capillaries in the intestinal villi? Answer: lipids 26. The nutrients that can be absorbed without preliminary processing but may involve special transport mechanisms are: Answer: water, electrolytes, and vitamins 27. The enzyme lactase, which digests lactose to glucose and galactose, is synthesized by: Answer: the stomach 28. Hydrochloric acid in the stomach functions primarily to: Answer: facilitate lipid digestion 29. The intestinal epithelium absorbs monosaccharides by: Answer: facilitated diffusion and cotransport mechanisms 30. When two fluids are separated by a selectively permeable membrane, water tends to flow into the solution that has the: Answer: higher concentration of solutes 31. An error in swallowing could most likely be detected by the: Answer: larynx 32. Many visceral smooth muscle networks show rhythmic cycles of activity in the absence of neural stimulation due to the presence of: Answer: pacesetter cells that spontaneously depolarize and trigger contraction of entire muscular sheets 33. The reason a completely dry food bolus cannot be swallowed is: Answer: friction with the walls of the esophagus makes peristalsis ineffective 34. Gastric glands, which produce most of the gastric juice, are abundant in which of the following regions of the stomach? Answer: A and B. a. fundus. b. body 35. The two factors that play an important part in the movement of chyme from the stomach to the small intestine are: Answer: stomach distension and gastrin release 36. The plicae of the intestinal mucosa, which bears the intestinal villi, are structural features that provide for: Answer: increased total surface area for absorption 37. The enteroendocrine cells of the intestinal crypts are responsible for producing the intestinal hormones: Answer: cholecystokinin and secretin 8. Villikinin, motilin, and somatostatin are produced in the: Answer: small intestine 39. The primary function(s) of the gastrointestinal juice is (are) to: Answer: all of the above. a. moisten the chyme. b. assist in buffering acids. c. dissolve digestive enzymes and products of digestion 40. An immediate increase in the rates of glandular secretion and peri staltic activity in all segments of the small intestine are a result of the: Answer: gastroenteric reflex 41. The primary effect of secretin is to cause a(n): Answer: increase in secretion of water and buffers by the pancreas and the liver 42. The peptide hormone that causes the release of insulin from the pancreatic islets is: Answer: GIP 43. How does the mucosa of the rectum compare with that of the colon and cecum? Answer: The colon and cecum are lined with a simple columnar epithelium for absorption, whereas the rectum is lined with stratified squamous epithelium because it is next to an opening to the exterior. 44. The muscular sphincter that guards the entrance between the ileum and the cecum is the: Answer: ileocecal valve 45. Which produces the least number of contractions to force food through the digestive tract on a daily basis? Answer: large intestine 46. The average composition of the fecal waste material is: Answer: 75% water; 5% bacteria; 20% indigestible materials, inorganic matter, and epithelial remains 47. The hormone gastrin: Answer: increases the activity of parietal and chief cells 48. The two positive feedback loops involved in the defecation reflex are: Answer: stretch receptors in rectal walls, and the sacral parasympathetic system 49. The ‘doorway to the liver' (porta hepatis) is a complex that includes the: Answer: bile duct, hepatic portal vein, and hepatic artery 50. Triglycerides coated with proteins create a complex known as a: Answer: chylomicron End of chapter Questions 1. The enzymatic breakdown of large molecules into their basic building blocks is called: †¢ (d)chemical digestion. 2. The outer layer of the digestive tract is known as the: †¢(a)serosa. 3. Double sheets of peritoneum that provide support and stability for the organs of the peritoneal cavity are the: †¢ (d)mesenteries. 4. A branch of the portal vein, hepatic artery, and tributary of the bile duct form †¢ (c)a portal area. 5. Label the digestive system structures in the following figure. a) oral cavity, teeth, tongue; (b) liver; (c) gallbladder; (d) pancreas; (e) large intestine; (f) salivary glands; (g) pharynx; (h) esophagus; (i) stomach; (j) small intestine; (k) anus 6. Label the four layers of the digestive tract in the following figure. (a) mucosa; (b) submucosa; (c) muscularis externa; (d) serosa 7. Most of the digestive tract is lined by ___________ epithelium. e. simple columnar. 8. Regional movements that occur in the small intestine and function to churn and fragment the digestive material are called: (a. )segmentation. 9. Bile release from the gallbladder into the duodenum occurs only under the stimulation of: (a. )cholecystokinin. 10. Label the three segments of the small intestine in the following figure. (a) duodenum; (b) jejunum; (c) ileum. 11. The major function(s) of the large intestine is (are): (a. )reabsorption of water and compaction of feces. (b. )absorption of vitamins liberated by bacterial action. (c. )storage of fecal material prior to defecation. (d. )a, b, and c. 12. Vitamins generated by bacteria in the colon are: (c)vitamin K, biotin, and pantothenic acid. 13. The final enzymatic steps in the digestive process are accomplished by: (a. ) brush border enzymes of the microvilli. 14. What are the six steps of digestion? Digestion involves (1. ) ingestion; (2. ) mechanical processing; (3. ) secretion; (4. ) digestion (conversion into a form usable by cells); (5. ) absorption; and (6. ) excretion. 15. Name and describe the layers of the digestive tract, proceeding from the innermost layer to the outermost layer. Layers of the digestive tract are (1. ) the mucosa: the epithelial layer that performs chemical digestion and absorption of nutrients; (2. the submucosa: the connective tissue layer containing lymphatic and blood vessels and the submucosal nerve plexus; (3. ) the muscularis externa: the smooth muscle layer containing the myenteric nerve plexus; and (4. ) the serosa: the outermost layer, epithelium and connective tissue that forms the visceral peritoneum (or connective tissue that forms the adventitia). 16. What three basic mechanisms reg ulate the activities of the digestive tract? Activities of the digestive tract are regulated by neural, hormonal, and local mechanisms. 17. What are the three phases of swallowing, and how are they controlled? The three phases of swallowing—the buccal, pharyngeal, and esophageal phases—are controlled by the swallowing center of the medulla oblongata via the trigeminal and glossopharyngeal cranial nerves. The motor commands originating at the swallowing center are distributed by cranial nerves V, IX, X, and XII. Along the esophagus, primary peristaltic contractions are coordinated by afferent and efferent fibers within the glossopharyngeal and vagus cranial nerves, but secondary peristaltic contractions occur in the absence of CNS instructions. 8. What are the primary digestive functions of the pancreas, liver, and gallbladder? The pancreas provides digestive enzymes, plus bicarbonate ions that elevate the pH of the chyme. The liver produces bile and is also the primary organ involved in regulating the composition of circulating blood. The gallbladder stores and releases bile, which contains additional buffe rs and bile salts that facilitate the digestion and absorption of lipids. 19. Which hormones produced by duodenal enteroendocrine cells effectively coordinate digestive functions? The hormones include the following: enterocrinin, which stimulates the submucosal glands of the duodenum; secretin, which stimulates the pancreas and liver to increase the secretion of water and bicarbonate ions; cholecystokinin (CCK), which causes an increase in the release of pancreatic secretions and bile into the duodenum, inhibits gastric activity, and appears to have CNS effects that reduce the sensation of hunger; gastric inhibitory peptide (GIP), which stimulates insulin release at pancreatic islets and the activity of the duodenal submucosal glands; vasoactive ntestinal peptide (VIP), which stimulates the secretion of intestinal glands, dilates regional capillaries, and inhibits acid production in the stomach; gastrin, which is secreted by G cells in the duodenum when they are exposed to large quantities of incompletely digested proteins; and, in small quantities, motilin, which stimulates intestinal contractions, villikinin, which promotes the movement of villi and associat ed lymph flow, and somatostatin, which inhibits gastric secretion. 20. What are the three primary functions of the large intestine? The large intestine reabsorbs water and compacts the intestinal contents into feces, absorbs important vitamins liberated by bacterial action, and stores fecal material prior to defecation. 21. What two positive feedback loops are involved in the defecation reflex? Positive feedback loops in the defecation reflex involve (1. ) stretch receptors in the rectal walls, which promote a series of peristaltic contractions in the colon and rectum, moving feces toward the anus; and (2. the sacral parasympathetic system, also activated by the stretch receptors, which stimulates peristalsis via motor commands distributed by the pelvic nerves. 22. During defecation, (a. )stretch receptors in the rectal wall initiate a series of peristaltic contractions in the colon and rectum. (b. )stretch receptors in the rectal wall activate parasympathetic centers in the sacral region of the spinal cord. (e. )only a and b occur. 23. Increased parasy mpathetic stimulation of the intestine would result in: (e. )none of these. 24. A drop in pH below 4. 5 in the duodenum stimulates the secretion of (a)secretin. 5. Through which layers of a molar would an oral surgeon drill to perform a root canal (removal of the alveolar nerve in a severely damaged tooth)? A root canal involves drilling through the enamel and the dentin. 26. How is the epithelium of the stomach protected from digestion? The stomach is protected from digestion by mucous secretions of its epithelial lining and by neural and hormonal control over the times and rates of acid secretion. 27. How does each of the three phases of gastric secretion promote and facilitate gastric control? (1. ) The cephalic phase of gastric secretion egins with the sight or thought of food. Directed by the CNS, this phase prepares the stomach to receive food. (2. ) The gastric phase begins with the arrival of food in the stomach; this phase is initiated by distension of the stomach, an incre ase in the pH of the gastric contents, and the presence of undigested materials in the stomach. (3. ) The intestinal phase begins when chyme starts to enter the small intestine. This phase controls the rate of gastric emptying and ensures that the secretory, digestive, and absorptive functions of the small intestine can proceed reasonably efficiently. 8. Nutritionists have found that after a heavy meal, the pH of blood increases slightly, especially in the veins that carry blood away from the stomach. What causes this â€Å"postenteric alkaline tide†? After a heavy meal, bicarbonate ions pass from the parietal cells of the stomach into the extracellular fluid, causing the pH of the extracellular fluid to rise. As the extracellular fluid exchanges ions with the blood, the blood pH also increases. 29. Some people with gallstones develop pancreatitis. How could this occur? If a gallstone is small enough, it can pass through the common bile duct and block the pancreatic duct. Enzymes from the pancreas then cannot reach the small intestine. As the enzymes accumulate, they irritate the duct and ultimately the exocrine pancreas, producing pancreatitis. 30. Harry is suffering from an obstruction in his colon. He notices that when he urinates, the color of his urine is much darker than normal, and he wonders if there is any relationship between the color of his urine and his intestinal obstruction. What would you tell him? The darker color of his urine is probably due to increased amounts of the pigment urobilin, which gives urine its normal yellow color. Urobilin is derived from urobilinogen, which is formed in the large intestine by the action of intestinal bacteria on bile pigments. In an intestinal obstruction, the bile pigments cannot be eliminated by their normal route, so a larger-than-normal amount diffuses into the blood, where it is eliminated by the kidneys. 31. A condition known as lactose intolerance is characterized by painful abdominal cramping, gas, and diarrhea. The cause of the problem is an inability to digest the milk sugar, lactose. How would this cause the observed signs and symptoms? If an individual cannot digest lactose, this sugar passes into the large intestine in an undigested form. The presence of extra sugar in the chyme increases its osmolarity, so less water is reabsorbed by the intestinal mucosa. The bacteria that inhabit the large intestine can metabolize the lactose, and in the process they produce large amounts of carbon dioxide. This gas overstretches the intestine, which stimulates local reflexes that increase peristalsis. The combination of more-fluid contents and increased peristalsis causes diarrhea. The overexpansion of the intestine by gas, which is directly related to increased gas production by the bacteria, causes the severe pain and abdominal cramping. 32. Recently, more people have turned to surgery to help them lose weight. One form of weight control surgery involves stapling a portion of the stomach shut, creating a smaller volume. How would such a surgery result in weight loss? The primary effect of such surgeries would be a reduction in the volume of food (and thus in the amount of calories) consumed because the person feels full after eating a small amount. This can result in significant weight loss. CheckPoints Page 882 1. Identify the organs of the digestive system. Organs of the digestive system include the esophagus, stomach, small intestine, large intestine, and accessory organs (salivary glands, liver, and pancreas). 2. List and define the six primary functions of the digestive system. The six primary functions of the digestive system include the following: (1) ingestion = consciously eating food; (2) mechanical processing = crushing and shearing foodstuffs to make them more susceptible to enzymatic attack; (3) digestion = the chemical breakdown of food into smaller products for absorption; (4) secretion = the release of water, acids, and other substances by the epithelium of the digestive tract and by glandular organs; (5) absorption = movement of digested particles across the digestive epithelium and into the interstitial fluid of the digestive tract; and (6) excretion = the removal of waste products from the body. . What is the importance of the mesenteries? The mesenteries—sheets consisting of two layers of serous membrane separated by loose connective tissue—support and stabilize the organs in the abdominopelvic cavity and provide a route for the associated blood vessels, nerves, and lymphatic vessels. 4. Name the layers of the gastrointestinal t ract from superficial to deep. The layers of the gastrointestinal tract, from superficial to deep, are the serosa, muscularis externa, submucosa, and mucosa (adjacent to the lumen). 5. Which is more efficient in propelling intestinal contents from one place to another: peristalsis or segmentation? The waves of contractions that constitute peristalsis are more efficient in propelling intestinal contents than segmentation, which is basically a churning action that mixes intestinal contents with digestive fluids. 6. What effect would a drug that blocks parasympathetic stimulation of the digestive tract have on peristalsis? A drug that blocks parasympathetic stimulation, which increases muscle tone and activity in the digestive tract, would slow peristalsis. Page 888 7. Name the structures associated with the oral cavity. Structures associated with the oral cavity include the tongue, salivary glands, and teeth. 8. Which type of epithelium lines the oral cavity? The oral cavity is lined by a stratified squamous epithelium, which provides protection against friction or abrasion by foodstuffs. 9. The digestion of which nutrient would be affected by damage to the parotid salivary glands? Damage to the parotid salivary glands, which secrete the carbohydrate-digesting enzyme salivary amylase, would interfere with the digestion of complex carbohydrates. 10. Which type of tooth is most useful for chopping off bits of relatively rigid foods? The incisors are the teeth best suited for chopping (or cutting or shearing) pieces of relatively rigid food, such as raw vegetables. 11. Where exactly in the human body is the fauces? The fauces is the dividing line between the oral cavity and the pharynx. 12. Describe the structure and function of the pharynx. The pharynx is an anatomical space that receives a food bolus or liquids and passes them to the esophagus as part of the swallowing process. 13. Identify the muscles associated with the pharynx. Muscles associated with the pharynx are pharyngeal constrictor muscles, the palatopharyngeus and stylopharyngeus muscles, and palatal muscles. Page 890 14. Name the structure connecting the pharynx to the stomach. The structure connecting the pharynx to the stomach is the esophagus. 15. Compared to other segments of the digestive tract, what is unusual about the muscularis externa of the esophagus? The muscularis externa of the esophagus is an unusual segment of the digestive tract because it (1) contains skeletal muscle cells along most of the length of the esophagus and (2) is surrounded by an adventitia rather than a serosa. 6. What is occurring when the soft palate and larynx elevate and the glottis closes? When the soft palate and larynx elevate and the glottis closes, swallowing (deglutition) is occurring. Page 897 17. Name the four major regions of the stomach. The four regions of the stomach are the cardia, fundus, body, and pylorus. 18. Discuss the significance of the low pH in the stomach. The low pH of the stomach creates an acidic environment that kills most microbes ingested with food, denatures proteins and inactivates most enzymes in food, helps break down plant cell walls and meat connective tissue, and activates pepsin. 9. How does a large meal affect the pH of blood leaving the stomach? Large (especially protein-containing) meals stimulate increased stomach acid secretion. Because the hydrogen ions of stomach acid come from blood entering the stomach, blood leaving the stomach will have fewer hydrogen ions and thus a higher pH. This phenomenon is referred to as the alkaline tide. 20. When a person suffers from chronic gastric ulcers, the branches of the vagus nerves that serve the stomach are sometimes cut in an attempt to provide relief. Why might this be an effective treatment? The vagus nerves contain parasympathetic motor fibers that can stimulate gastric secretions, even if food is not present in the stomach (the cephalic phase of gastric digestion). Cutting the branches of the vagus nerves that supply the stomach would prevent this type of secretion from occurring and thereby reduce the likelihood of ulcer formation. Page 910 21. Name the three regions of the small intestine from proximal to distal. The three regions of the small intestine are the duodenum, jejunum, and ileum. 22. How is the small intestine adapted for the absorption of nutrients? The small intestine has several adaptations that increase its surface area and thus its absorptive capacity. The walls of the small intestine are thrown into folds, the plicae circulares. The tissue that covers the plicae circulares forms fingerlike projections, the villi. The cells that cover the villi have an exposed surface covered by small fingerlike projections, the microvilli. In addition, the small intestine has a very rich supply of blood vessels and lymphatic vessels, which transport the nutrients that are absorbed. 23. Does a high-fat meal raise or lower the level of cholecystokinin in the blood? A high-fat meal would raise the cholecystokinin level in the blood. 24. How would the pH of the intestinal contents be affected if the small intestine did not produce secretin? The hormone secretin, among other things, stimulates the pancreas to release fluid high in buffers to neutralize the chyme that enters the duodenum from the stomach. If the small intestine did not secrete secretin, the pH of the intestinal contents would be lower than normal. 25. The digestion of which nutrient would be most impaired by damage to the exocrine pancreas? Damage to the exocrine pancreas would most impair the digestion of fats (lipids), because it is the primary source of lipases. Even though such damage would also reduce carbohydrate and protein digestion, enzymes for digesting these nutrients are produced by other digestive system structures, including the salivary glands (carbohydrates), the small intestine (carbohydrates and proteins), and the stomach (proteins). Page 916 26. Identify the four regions of the colon. The four regions of the colon are the ascending colon, transverse colon, descending colon, and sigmoid colon. 27. What are some major histological differences between the large intestine and the small intestine? The large intestine is larger in diameter than the small intestine, but its relatively thin wall lacks villi and has an abundance of mucous cells and intestinal glands. 28. Differentiate between haustral churning and mass movements. In mass movements, which occur a few times per day throughout the transverse colon and the distal portions of the large intestine, strong peristaltic contractions move material along the length of the colon. In haustral churning, segmentation movements mix the contents of adjacent haustra. Page 921 29. What kinds of nutrients does the body require? Nutrients required by the body are carbohydrates, lipids, proteins, vitamins, minerals, and water. 30. What component of food would increase the number of chylomicrons in the lacteals? Because chylomicrons are formed from the fats digested in a meal, fats increase the number of chylomicrons in the lacteals. 31. The absorption of which vitamin would be impaired by the removal of the stomach? Removal of the stomach would interfere with the absorption of vitamin B12, a process that requires intrinsic factor, produced by the parietal cells of the stomach. 2. Why is it that diarrhea is potentially life threatening, but constipation is not? When an individual with diarrhea loses fluid and electrolytes faster than they can be replaced, the resulting dehydration can be fatal. Although constipation can be quite uncomfortable, it does not interfere with any life-supporting processes; the few toxic waste products normally eliminated by the digestive system can move into the blood and be eliminated by the kidneys. Page 922 33. Identify general digestive system changes that occur with aging. General age-related digestive system changes include decreased secretory mechanisms, decreased gastric and intestinal motility, decreased mitotic activity of epithelial cells, and loss of tone; cumulative damage becomes more apparent, cancer rates increase, and dehydration occurs as a result of decreased osmoreceptor sensitivity. 34. Identify the functional relationships between the digestive system and other body systems. The digestive system absorbs the organic substrates, vitamins, ions, and water required by cells of all other body systems. 35. What body systems may be affected by inadequate calcium absorption? The skeletal, muscular, nervous, endocrine, and cardiovascular systems may all be affected by inadequate absorption of calcium. Review Questions Labeling 1. Label the following histological structures of the digestive tract from the image of the small intestine section. 1. 1 myenteric plexus D. 1. 2 submucosal gland A. 1. 3mucosa B. 1. 4serosa (visceral peritoneum) E. 1. 5 submucosa F. 1. 6muscularis externa C. 2. match the terms with the appropriate regions and structures of the stomach. 2. 1 fundus D. 2. 2 oblique muscle layer overlying mucosa E. 2. 3circular muscle layer B. 2. 4cardia C. 2. rugae F. 2. 6pyloric sphincter A. 3. Correctly match the terms with the appropriate structures of the liver lobule. 3. 1 central vein B. 3. 2 hepatocytes A. 3. 3 bile duct F. 3. 4 bile canaliculi E. 3. 5sinusoid C. 3. 6Kupffer cells D. Matching 1. Put the following structures involved in bile transport in the proper order, from the liver to the gallbladder and on to the small intestine, by matc hing them (1) through (6): Bile canaliculi Bile ductules Right and left hepatic ducts Common hepatic ducts Cystic duct Common bile duct 2. Match the following cells and glands with their correct products: 2. Parietal cell HCl 2. 2Chief cell . Pepsinogen 2. 3G cells Gastrin 2. 4Intestinal glands Cholecystokinin 2. 5Brunner glands Urogastrone 3. Match the following substrates and products with the enzyme that catalyzes the reaction: 3. 1 Proteins to short-chain polypeptides . Pepsin 3. 2Dipeptides and tripeptides to amino acids Exopeptidase 3. 3trypsinogen to trypsin Enterokinase 3. 4A disaccharide to monosaccharides . Lactase 4. Match the following intestinal hormones to their correct functions: 4. 1Gastrin . This stimulates of increased motility in the stomach and the production of acids and enzymes. . 2Gastric inhibitory peptide . Secreted when fats and especially glucose enters the intestine, this enzyme triggers the release of insulin at the pancreas. 4. 3Cholecystokinin This is secreted when chyme is rich in lipids and partially digested proteins. It triggers the opening of the hepatopancreatic sphincter. 4. 4 Enterocrinin . This is released when chyme enters the small intestine and it stimulates mucin production. 5. Match the organ of the digestive system with its function: 5. 1Mastication of food . Teeth 5. 2Carries solid foods and liquids to the stomach . Esophagus . 3Bulk storage of ingested food, chemical and mechanical breakdown of ingested food, and production of the intrinsic factor . Stomach 5. 4Digestion and absorption of nutrients . Small intestine 5. 5Reabsorption of water, absorption of important vitamins, and storage of fecal matter . Large intestine 5. 6 Temporary storage of fecal matter . Rectum Multiple Choice 1. Which of the following is a function of the digestive tract? Answer: a. Ingestion b. Digestion c. Excretion d. Absorption 2. From the outside in, the correct order of the layers of the digestive tract is Answer: erosa, muscularis externa, submucosa, mucosa. 3. The movements of the muscularis externa are coordinated by the Answer: myenteric plexus. 4. Waves of smooth muscle contraction that propel materials along the digestive tract are called Answer: peristalsis. 5. The mesentery that hangs like an apron from the lateral and inferior portion of the stomach is the Answer: greater omentum. 6. The lingual frenulum Answer: a. connects the tongue to the floor of the oral cavity. b. is a thin fold of mucous membrane. c. may need to be cut if the condition of ankyloglossia exists. 7. Incisors are used for Answer: lipping or cutting. 8. The mucosa and submucosa of the esophagus are folded for Answer: to allow the expansion of the esophagus during the passage of a large bolus. 9. Which of the following is a function of the stomach? Answer: a. Mechanical breakdown of food b. Production of intrinsic factor 10. Chief cells secrete Answer: pepsinogen. 11. When the stomach is empty, the mucosa is thrown into folds called Answer: rugae. 12. When you walk into a Mexican restaurant and smell the savory aroma of fajitas, which phase of gastric activity is triggered? Answer: Cephalic phase 13. Peyer patches Answer: re lymphoid nodules located in the ileum. 14. The wall of the small intestine bears a series of folds called the Answer: plicae circulares. 15. The duodenum differs from the rest of the small intestine in that its submucosa contains many __________ that secrete mucus. Answer: Brunner glands 16. The gastroenteric reflex stimulates motility Answer: along the entire length of the small intestine. 17. Sympathetic stimulation Answer: inhibits submucosal glands. 18. Concentrated crystals of minerals and salts in the gallbladder produce Answer: a condition called cholelithiasis. 19. Pancreatic juice is Answer: alkaline. 20. Which of the following is not a function of the liver? Answer: Immunologic regulation 21. Liver cells, or hepatocytes, receive blood from the Answer: a)hepatic artery. b)hepatic portal vein. 22. Bile acts as a(n) Answer: emulsifier. 23. The defecation reflex Answer: a. involves long and short reflexes. b. involves two positive feedback loops. 24. The large intestine absorbs which of the following vitamins from colonic bacteria? Answer: a. Biotin b. Vitamin B5, or pantothenic acid c. Vitamin K 25. Fat-soluble vitamins move across the intestinal mucosa by Answer: iffusion. True and False 1. The pharynx belongs to both the respiratory and digestive systems. Answer: True As air is inhaled it passes through the pharynx into the trachea, and as food is swallowed it passes through the pharynx into the esophagus. 2. Cuspids are cutting or clipping teeth. Answer: False Incisors are cutting or clipping teeth. 3. A drop in the pH of the chyme coming from the stomach trigge rs the release of CCK. Answer: False CCK is a hormone released when chyme is full of fatty acids and triglycerides. 4. The haustra are formed by contraction of the taenia coli. Answer: True Expansion and elongation of the colon is accomplished by haustra; how do the haustra expand and elongate? 5. The region of the tooth between the crown and the root is called the gingival space. Answer: False The gingival space is between the gum and the tooth. Fill In the Blank 1. The muscularis externa propels materials from one portion of the digestive tract to the other by a series of wavelike contractions called peristalsis, while in most areas of the small intestine ___ segmentation _______ movements churn and fragment digestive materials. 2. Pancreatic juice is secreted by units known as pancreatic ____ acini ______. 3. ___ Peptidases _______ are proteolytic enzymes that break small peptide chains into amino acids. 4. The transverse folds that make up the intestinal lining and provide more surface area for absorption are called __ plicae ________. 5. The glycoprotein __ intrinsic factor ________, necessary for vitamin B12 absorption, is produced in the stomach. Multiple Choice 2 1. The layer of the digestive tract that contains large blood vessels, lymphatics, and a network of nerve fibers called the plexus of Meissner is the Answer: ubmucosa. 2. Each of the following products of digestion is taken up by capillaries in the small intestine except one. Identify the exception. Answer: Chylomicrons 3. Which of the following statements is false concerning the teeth? Answers: Dentin, the material that makes up the enamel of the teeth, is a type of spongy bone, thus giving the tooth its hardness. A layer of a material called ce mentum covers the dentin of the root and attaches the tooth to the periodontal ligament. 4. Which salivary glands produce a thick serous secretion containing large amounts of salivary amylase? Answer: Parotid glands . Which type of tooth is conical with a pointed tip and used for tearing and slashing? Answer: Cuspids or canines 6. During the pharyngeal phase of deglutition Answer: the larynx elevates and the uvula and soft palate block the nasopharynx. 7. Which of the following statements is false concerning aging and the digestive system? Answer: Dehydration becomes less common as a result of the body's inability to effectively rid itself of water. 8. Which of the following is not a pancreatic enzyme? Answer: Pepsinogen 9. Which of the following statements is false regarding the Kupffer cells of the liver? Answer: Kupffer cells have the ability to produce bile. 10. Of the 1,500 mL of material that enters the large intestine on a daily basis, approximately how much water in the material is reabsorbed? Answer: 1,200 mL 11. During the defecation reflex Answer: parasympathetic centers in the sacral region of the spinal cord stimulate mass movements. 12. Each of the following is a brush border enzyme except one. Identify the exception. Answer: Amylase 13. Fatty acids and monoglycerides interact with the bile salts in chyme to form small, lipid-bile salt complexes called Answer: micelles. 4. Peyer patches are associated with which region of the intestine? Answer: Ileum Peyer patches are aggregates of lymphoid tissue found in the ileum. 15. Treatment for a morbidly obese man includes surgery to reduce the length of his intestine. Which region of the small intestine should be removed to achieve greatest weight loss? Answer: Jejunum The jejunum is responsible for the majority of chemical digest ion and nutrient absorption. Section 2: Concept Review Now let's see what you have learned about Digestion and Absorption. I will give you a question and two possible answers. Then I will pause while you consider the choices and select your answer. After a few seconds, I will give you the correct answer with an explanation. Question 1 Enzymes and buffers are considered part of which type of digestion? Is it A) mechanical or B) chemical? The answer is B) chemical. Mechanical digestion involves mixing, churning, and chewing. Question 2 What do we call movement of food without direction in the digestive tract? Is it A) peristalsis or B) segmentation? The answer is B) segmentation. Peristalsis is the movement of food forward through the digestive tract. Question 3 Where does major absorption of food substances occur? Is it in A) the stomach or B) the small intestine? The answer is B) the small intestine. Almost all absorption occurs in the small intestine. Question 4 Which type of enzyme digests carbohydrates? Is it A) amylase or B) peptidase? The answer is A) amylase. Peptidase breaks down proteins. Question 5 Which side of the epithelial cells lining the digestive tract faces in towards the lumen? Is it A) apical or B) basal? The answer is A) apical. The basal surface fuses the cells to the deep tissues. Question 6 What is the term for emulsified, digested lipids? Is it A) chylomicrons or B) micelles? The answer is B) micelles. Chylomicrons are cholesterol-fat complexes that have a protein coating. Question 7 Which portion of the small intestine serves as a mixing bowl for substances from the pancreas, liver, and stomach? Is it A) the duodenum or B) the ileum? The answer is A) the duodenum. As the food enters the small intestines, enzymes, buffers, and bile also enter at the duodenum Question 8 In which part of your digestive system is most of the water reabsorbed? Is it A) the colon or B) the small intestine? The answer is B) the small intestine. Up to ninety-five percent of the water entering the digestive tract is absorbed here. That's the end of this section. Section 3: Rapid Review Now we will do a quick set of review questions on Digestion and Absorption. I will give you a question and then only a couple of seconds to give your answer. After a brief pause, I will give you the correct answer. Let's start with some true or false questions. Question 1 True or false? Bile is produced by the gallbladder. Answer: False Question 2 True or False? Once food is digested in the stomach, it is called chyme. Answer: True Question 3 A chylomicron is an example of a digested protein. Answer: False Okay, now let's try some multiple choice questions. Question 4 Which substance is absorbed through the intestinal lining? Is it A) monosaccharides or B) nucleic acids? Answer: A) monosaccharides Question 5 What is the term for breaking down lipids? Is it A) lipogenesis or B) emulsification? Answer: B) emulsification Great! Now let's try some short answer questions. Question 6 Which accessory organ produces amylases, lipases, buffers, and hormones? Answer: The pancreas Question 7 Most of the fat absorption occurs in which part of the small intestine? Answer: The ileum Question 8 Where does the process of chemical digestion start? Answer: In the mouth That's the end of this section.

Marketing Ppt

PROJECT REPORT OPERATIONS MANAGEMENT GUIDED BY:PRESENTED BY: Prof. T. T. NIRANJANNITIN BANSAL 129278039 RANJAN SAHU 129278041 ROHIT MANGAL 129278053 SAURABH SINHA 129278057 Project Report On| | | | Taxonomy of Implementation Problems in VMI| | Contents Executive summary3 Introduction4 Under the typical business model:4 Vendor Managed Inventory model:4 Consignment Inventory:4 Vendor Managed Inventory and Stakeholder’s Challenges5 Challenges faced in implementation of Vendor Managed Inventory7 Analysis of Cases of implementing Vendor Managed Inventory9 Conclusion11 References12 Executive summaryThe goal of Vendor Managed Inventory is to provide a mutually beneficial relationship where both sides Customer and Vendor will be able to control the availability and flow of goods more smoothly and accurately. In  VMI  a manufacturer or distributor assumes the role of inventory planning for the customer. Extensive information sharing is required so that the manufacturer/distributor can maintain a high degree of visibility of its goods at the customer’s location. Instead of the customer reordering when its supply has been exhausted, the supplier is responsible for replenishing and stocking the customer at appropriate levels.Wal-Mart has mastered  VMI  and is the company against which many other organizations benchmark themselves. This report covers various issues that are to be considered to implement the Vendor Managed Inventory. It is realized in the report that several risks are to be considered while executing VMI. The proper analysis is done in seeking the scenarios where one issue becomes a key factor in deciding to implement VMI or not. Both Marketers and Distributors have their own issues to challenge the implementation of VMI. Focus of the report is to determine taxonomy of implementation problems in VMI.Introduction A means of optimizing Supply Chain performance in which the manufacturer is responsible for maintaining the distributorâ€℠¢s inventory levels. The manufacturer has access to the distributor’s inventory data and is responsible for generating purchase orders. We can see the differences in maintain inventory as: Under the typical business model: When a distributor needs product, they place an order against a manufacturer. The distributor is in total control of the timing and size of the order being placed. The distributor maintains the inventory plan.Vendor Managed Inventory model: The manufacturer receives electronic data (usually via EDI or the internet) that tells him the distributor’s sales and stock levels. The manufacturer can view every item that the distributor carriers as well as true point of sale data. The manufacturer is responsible for creating and maintaining the inventory plan. Under VMI, the manufacturer generates the order*, not the distributor. *Note: VMI does not change the â€Å"ownership† of inventory. It remains as it did prior to VMI. Consignment Inventory:When the supplier places inventory at a customer’s location and retains ownership of the inventory. Payment is not made until the item is actually sold. A VMI relationship may or may not involve consignment inventory. Vendor Managed Inventory and Stakeholder’s Challenges Vendor Managed Inventory primarily have various stakeholder’s involved which includes Vendor/Manufacturer or distributor and retailer. Let us examine challenges faced by each: Challenges in VMI Implementation from vendor’s side High administrative costs: – Suppliers would have to face higher administrative costs.They will have to allocate additional staff resources to properly manage the replenishment activities that were previously managed by the retailer. So to overcome these additional costs, vendors must have to save enough money from the inventory costs and sufficient sales volumes and gross margins Loss of market share due to less shelf coverage: – VMI would help in reducin g the inventory which could lead to the less coverage of the shelf space on the retailer’s shop which might lead to the reduction in the market share for that product.To resolve this issue, vendor can provide more stock keeping units of the same product to fill the shelf space and to maintain the market share. Challenges in VMI Implementation from retailer’s side Loss of Control: – If VMI is implemented, then there is always a fear in the mind of the retailer that he would loose his control over the operations management. All the decisions like when to order, how much to keep as inventory and when to sell the product would be managed by the vendor now which can also have some impact on the profit margin of the retailer.Eg. In many cases, Vendor gives discounts to the retailer if they buy in bulk and hence above mentioned questions become crucial for the retailer from financial point of view. In case of products with high shelf life, he might want to order in bul k once, instead of ordering in small lots. Danger of being replaced: – Retailer would be afraid that after implementing of VMI, when almost all the operations management related decisions are taken by the vendor, then the vendor might also think of forward integrating.Hence he would not be fully cooperative in sharing of the data and he would always try to make his presence felt in decision making to show the importance of his role. Fear of losing other vendors: – The retailer would be afraid of losing other vendors, since in the FMCG business; retailers get products from a lot of vendors to maintain variety for the customers. It would be difficult to choose the vendor who will manage the inventory, because the same vendor would be biased towards his products.This would lead to the development of bad relationship between the retailer and the other vendors. After implementation of VMI, forecasting of demand is done by the manufacturer, not by the retailers or distributo rs and it might hit back, if manufacturer is not competent in judging the patterns of the consumer demand. Challenges faced in implementation of Vendor Managed Inventory Personal Factors Trust: – One of the most important factors which can contribute to the success of the VMI is trust and good relationship between the vendor and the downstream retailer.But in the FMCG sector, where there are a lot of products in the same segment, most of the retailers are unwilling to share their data related to their sales with anyone, even with their supplier. This leads to the ineffective communication between them and both have to incur huge inventory and management costs. Work ethics and cultural differences: – Each company has its set of work ethics and work culture and if the difference is huge for a vendor and the retailer, then their decisions would not be aligned. Technical IssuesTechnology is one of the most critical factors in facilitating the implementation of VMI which ca n also stand as a challenge in the implementation of VMI. A lot of technical systems would have to be installed for the effective working of the VMI. Some of the technical solutions that can facilitate an effective VMI arrangement include: †¢ Electronic data exchange (EDI). EDI transactions can enable suppliers to efficiently manage customer inventory levels remotely. †¢ Replenishment software. These applications allow customers to accurately assess projected service levels (i. . the percentage of requests that can be filled from stock) based on various inventory investments. †¢ Bar coding or radio frequency identification (RFID). These technologies â€Å"tag† products for tracking purposes and can dramatically improve the speed and integrity of the collection and reporting of consumption data. †¢ Forecasting software. These applications gather and analyze information from sales, accounting, order entry, and other business systems, using sophisticated algo rithms and predictive modeling techniques to generate fast, accurate demand forecasts.Investment- A lot of investment would be required to install and maintain any of these systems. Properly equipped manpower would be required to operate these tools. Investment would also be required to integrate these tools with each other for efficient functioning of the VMI operations. All this cost would have to be incurred by the vendor and to compensate this cost, he must get returns from the efficient inventory management and higher sales volume due to less stock-outs. Testing- It requires a lot of time and money in testing the various VMI systems after installing them.An extensive testing has to be done for the EDI system before giving it a final green flag for the VMI system. Analysis of Cases of implementing Vendor Managed Inventory Let’s discuss some cases where VMI is implemented: Barilla Spa Case Barilla is largest manufacturer of â€Å"fresh† and â€Å"dry† pasta p roducts with more than 1000 SKUs. It has sales of around $2B and very stable demand at retail level. Challenges it was facing are as under: Retailers didn’t have large inventories to accommodate new products introduced from time to time.Stock outs are quiet frequent at DO’s. Thin margins for both manufacturers and retailers are adding to the problem. Solution offered through VMI: Downstream distribution Center (DC) reports inventory and sales data electronically to Barilla on a daily basis. Barilla is managing the inventory of DC and decides how much to ship to them. According to  Industry Week's Best Plants 2006 Statistical Profile, 56% of the top 25 plants between 2002 and 2006 have used â€Å"resident suppliers† to manage or replenish inventory.However, the average percentage of purchased materials and components (dollar volume) managed by on-site suppliers is only 13. 7%. So, it seems, there is a time and place for vendor-managed inventory. For example, if you've got an expensive manufacturing line and you ask one of your key suppliers to put in the systems and develop the expertise to supply the goods you need on a just-in-time basis, they will do that if they receive a significant portion of their revenues from you, says Steve Banker, service director of supply chain management at ARC Advisory Group, Dedham, Mass. However, you may have a lot of suppliers where you are only 1% of their total revenue — you are not their biggest priority,† Banker says. â€Å"The chances that they will take on added responsibility and costs to manage your inventory is low. † So we can see that size of the business does matter in determining the feasibility of implementing VMI.In addition, there is a certain amount of IT integration that has to go on in order to make the VMI relationship work. For suppliers, they need to be able to get your forecasts on a regular basis, make intelligence out of them and have visibility into your inve ntory levels on an ongoing basis,† says Banker. â€Å"Turning that into useable intelligence is kind of difficult. Small and midsized companies often don't have the dedicated IT resources to make that happen, so they struggle. † â€Å"Resident Suppliers† Manage/Replenish Inventory (% Of Plants) Year| No| Yes| 2002| 44| 56| 2003| 52| 48| 2004| 48| 52| 2005| 32| 68| 2006| 44| 56| 2002-2006| 44| 56| Source: Industry Week's Best Plants 2006 Statistical ProfilePercentage Of Purchased Materials And Components (Dollar Volume) Managed By On-Site Suppliers Year| Median| Mean| Minimum| Maximum| 2002| 5. 0| 24. 4| 0. 0| 100. 0| 2003| 0. 0| 12. 2| 0. 0| 100. 0| 2004| 4. 0| 15. 2| 0. 0| 70. 0| 2005| 6. 0| 13. 8| 0. 0| 67. 0| 2006| 4. 2| 15. 1| 0. 0| 95. 0| 2002-2006| 3. 0| 13. 7| 0. 0| 100. 0| Source: Industry Week's Best Plants 2006 Statistical Profile Similarly, we have case of P&G which successfully employed Vendor managed Inventory while ODLO isn’t so successful in implementing the same.Also companies like RUAG aren’t having any financial or strategic benefit out of implementing VMI and hence didn’t go for it. If we analyze the sector in which they operates we come to know, RUAG which is in Airlines sector involves comparatively simpler inventory to maintain while the risk involved in giving away the details was higher. On the other hand, with the scale of business P&G is in, it is beneficial for both manufacturer (vendor) as well as distributor (or Retailer) to implement VMI. It can be seen both scale and sector favors P&G.GRENDENE, one of the world's largest footwear manufacturers, implemented Agentrics' Vendor Managed Inventory (VMI) solution and aligned its product replenishment process with the real demand of regional distributors/customers, thus increasing service level, optimizing stocks and boosting sales. ACHIEVED RESULTS: Increase of accuracy in sales forecasts; Increase of sales by 47% for participating retailers; Imp roved management of a product mix, by reducing or discontinuing low-performance and low-turnover products;   Streamlined replenishment of high-performance products;Excellent overall result with customers using the solution. VONPAR With Agentrics' VMI solution, acquired a full, web-based supply chain KPI tool. Vonpar Refrescos, Brazil's fourth largest Coca-Cola bottling company with products reaching 14 million consumers, implemented Agentrics' Vendor Managed Inventory (VMI) solution and with it acquired a complete web-based KPI tool. KPI's track internal and client stock levels, demand planning, order administration, as well as automation of Vonpar's product replenishment process, improving service and optimizing stock levels, while improving customer relationships.ACHIEVED RESULTS : Average sales increase of 26 percent in the first 12 months after the solution's implementation; Significant increase in sales of juices, tea and beer, which reflects improved stock planning for great er availability of products at store level; Maximized speed in the exchange of sales information at store level; Stock optimization allowing Vonpar to have the right product at the right time in the right place; Commercial team freed up to focus on avoiding out-of-stocks. SYNGENTA Implemented Agentrics' VMI solution to manage stock jointly with its suppliers.Syngenta, a world-leading agri-business committed to sustainable agriculture through innovative research and technology, implemented Agentrics' Vendor Managed Inventory (VMI) solution to manage stock in conjunction with its suppliers ACHIEVED RESULTS: Reduction of communication errors through process automation and visibility to inventories. â€Å"Today, our customers say that for the first time in the agricultural market, a company is able to co-manage inventory demand like large retail chains,† says Marcos Mazza, Supply Chain Manager. NeoGrid has a solution that perfectly suits our business model; Syngenta did not have to adapt to the tool, as the solution metall our needs. † Marcos Mazza, Supply Chain Manager. Conclusion The main purpose of this report is to highlight the taxonomy of implementation problems in VMI. From the cases visited, we can deduce that various factors play key roles in determining whether to go for Vendor Managed Inventory as there are lot of issues and cost involved in implementing the same.Size of the business, Sector of the business in operation, inter-relationship among stakeholders all plays equally important role in the actual decision making. Though there is no clear cut understanding on whether to implement VMI or not but one can easily concur with increasing role of technology and with dynamic demand it is only going to rise.References Williams, M. (1998). Making Consignment and Vendor-Managed Inventory Work For You. APICSInternational Conference. Schreibfeder, J. (1997). Vendor Managed Inventory: there’s more to it than just sell products. Effective In ventory. com Collaborative Planning, Forecasting, and Replenishment Committee. (1998)  Jointly Managed Inventory Approach Provides a Lower Level of Detail. CPFR. Org http://www. scm. ethz. ch/publications/Practitioner_publications/Niranjan_etal_2011_Are_you_ready_for_VMI. pdf http://www. emeraldinsight. com/journals. htm? articleid=1620974;show=abstract http://openarchive. cbs. dk/handle/10398/8229 http://www. supplyon. com/vendor-managed-inventory_at_zf. html http://www. industryweek. com/procurement/vendor-managed-inventory-size-matters

Main Theme of Lord of the Flies Essay

I think William Golding purposely chose the same setting as The Coral Island, but with a different ending of course, showing readers that us humans beings, as hard it might be to admit, unfortunately we have a wicked side and without supervision castigation to keep it in check. This sophisticated society that we live in would’ve turned into a barbaric anarchy instantly and still today, we have people who choose to ignore the civilization, take the risk and act like savages despite the â€Å"sophisticated society† but those people end up in jail. One of the major themes, isolation. What better way can you put it? The boys are stranded on an island, not mentioning the fact that they are still kids, innocent kids without adult supervision. This was obviously slowly making them hopeless as they realize that there is no way they’ll be rescued. But if you give it some thought, the island is similar to our society in many ways. Firstly, Golding makes the conch delineate power and authority, like the government today, because whoever held the conch in the story had the authority to speak. That rule is official when Ralph says â€Å"And another thing. We can’t have everybody talking at once. We’ll have to have hands up like at school then I’ll give him the conch.† (Golding 31) This shows the effort Ralph was putting into bringing rules and order so it could bring all the other boys closer together as a society. The island is basically a microcosm, Golding uses it to imitate our world while giving comments and his own view of human nature and how it is. For that to happen, he uses objects that are symbolic referring to his ideas like the previous example I gave about the Government. Golding also uses the characters that duplicate historical and/or religious people and finally the setting where all the conflicts happen, having parallels in the real world and society. The boys show what happened in the story isn’t just a story. They help present Goldings belief that humankind is savage and evil under all that civilization. So, Lord of the flies is a microcosm, just in a smaller civilization. The physical location (the remote island) which Golding set to serve the theme of constructing civilisation. However, as the stranded boys progressed on this island together, savagery eventually invaded their instincts and this helped develop the theme of loss of innocence. Again, this story was set on an isolated island, it had all you needed, food, wood for shelter and fire and no dangerous animals, there werent any humans either, the boys were probably the first to set a foot on this island. As Ralph, Jack and Simon were climbing the hill for the first time together, they noticed the tracks and started wondering who them. They started following. â€Å"Animals† were Ralph’s answer. The setting here was kind of like paradise for the boys, it took all of society’s rules and orders on behavior and allowed the boys to do whatever they want, since they were in charge this time.

America History19th Essay Example | Topics and Well Written Essays - 1500 words

America History19th - Essay Example However, in ‘The Yellow Wallflower’ the author has provided a scenario which indicates the dominance of men over women in the second half of nineteenth century. Both these literary works give a contradicting view of the gender roles in the society. The ‘Hospital Sketches’ is a short account of the experiences of a woman who worked as a nurse during the Civil War. The story starts with a woman who is trying to figure out what she wants to do in her life. After turning down a number of suggestions like; teaching, writing a book, acting and getting, she finally determines to nurse the soldiers in the Civil War. This starting of the story suggests the freedom of the women to choose what they want to do in their life. The setting of the story also suggests that the decisions of the women were also encouraged. The author is strong supporter of female equality. In her journey to become a nurse, she is helped by a number of gentlemen. The story further provides the account of the author regarding learning how to nurse and the difficulties faced by the author in the process. Throughout the story, the author provides an indication of the importance of women in the society. ... Thus, the author defines the roles of gender in the society by providing a convincing example. Since the author supports female equality, she has provided a convincing example of how men and women can work together in society for better results. However, ‘The Yellow Wallpaper’ is a story of a woman who is compelled to be confined within the bounds of a room and ultimately the psychological impacts of such confinement on the woman. The story provides a completely contradicting account of the gender roles in the second half of the nineteenth century when it is compared to the ‘Hospital Sketches’. The author tells the story in first-person perspective and she has written it in the style of journal entries. The story starts when a family goes to a colonial mansion for the summer and the woman who tells the story is confined in a room upstairs. Throughout the summer, she remains confined in that room with nothing to stimulate any of her feelings. The story provid es a gradual account of the woman’s descent into madness. With nothing else to interact with, the woman finds interest in the yellow wallpaper of the room. She finds it unnaturally intriguing. She closely inspects the pattern of the wallpaper and she perceives it to be more than ordinary wallpaper. The woman obsessively describes the wallpaper and claims that it has a unique â€Å"yellow† smell. After observing the wallpaper for days, she perceives a figure trapped in the wallpaper. She thinks that there is woman trapped in the wallpaper and in order to free her, she starts removing the paper off the wall. From a critical perspective, it can be said that the author is trying to represent the women

Art Essay Example | Topics and Well Written Essays - 1000 words - 12

Art - Essay Example The Last Judgment is a painting on fresco done by Michelangelo between 1536 and 1541. The painting is at the wall behind the altar at the Vatican Sistine chapel. The fresco is considered to be a breath taking and among Michelangelo’s last art works. In this art piece, Michelangelo depicts the end of the world and the imminent judgment. In this work, all the subjects are stripped naked; symbolizing the stripping of all earthly ranks, and they all appear equal before Christ (Burke 93). The whole painting radiates around Christ and the saved people can be seen rejoicing in light while the damned are being siphoned into the dark underworld. The painting was commissioned by Pope Paul III, who had a lot of faith in Michelangelo’s artistic proficiency. As a religious piece, the work was criticized for its use of nudity, but the Pope did not see any mishap. The painting was also not entirely relying on the bible as it would have been expected; it drew a lot of inspiration from mythological creatures like Charon, seen pulling unsaved subjects and judge Minos as a judge in the underworld (Burke 94). The subject matter of the whole piece is The Last Judgment, and it is depicted as an event where all people will be equal. The only thing that makes the difference is their earthly character, which would condemn them to the heavenly kingdom or to the underworld suffering. This is seen as the damned are crying as they are ferried by Charon towards the underworld where judge Minos is judging them (Burke 95). The saved people are seen rejoicing and happy before the lighted ring with Christ their savior welcoming them. The art piece includes many saints who have in their hands the weapons of their martyrdom that contrasts the actual scene of torture. An example is Saint Bartholomew who was skinned alive. As a martyred said, Bartholomew is seen holding his skin in his left hand and a knife in his right hand. The skin is believed to be a portrait of the artist, which is

Process Paper on How to Choose a Cell Phone Plan Or How to change a Essay

Process Paper on How to Choose a Cell Phone Plan Or How to change a Tire - Essay Example However, shopping for a cell phone plan doesnt have to be any more complex than shopping for a new pair of tennis shoes. Selecting the proper cell phone plan is really just a matter of finding the provider that covers your area, provides enough minutes to cover your usage pattern, and includes any extra features, such as texting, that you might want to use. The first decision you will need to make when selecting a cell phone plan is to pick the best provider for your area. It is important to know that not all cell phone companies cover all areas. In addition, some services will have dead spots where a cell phone will not work. Local salespeople may be reluctant to tell you about poor coverage or known dead spots. However, the carriers websites usually have a map of the coverage that they have in the area, as well as any dead zones. There are also websites, such as mobiledia.com, that offers coverage maps, tower maps, consumer feedback, and links to the major carriers (Mobiledia). In addition, family and friends in the area can usually be the most reliable source of information. Once you have selected the carrier that has adequate coverage for your area, you can select the best plan that they have available that fits your specific needs. To select the best plan for your needs you will need to determine when and how often that you use your wireless phone. Most plans are sold with a limited number of minutes that can be used for talking through the week during the day. In addition, many plans come with free nights and weekends. If you do most of your talking at night, you may be able to have a plan that has fewer daytime minutes. If most of your usage is during the day, you may want to get more daytime minutes. Dont underestimate your amount of use. Remember, your cell phone is always with you and turned on. It isnt surprising that almost two thirds of the respondents in a recent survey said they use their cell phone significantly more than a

African Tribal Dances Essay Example | Topics and Well Written Essays - 1750 words

African Tribal Dances - Essay Example Furthermore, when they dance, for them all time stops, the air draws back and the past, the present and the future merge into a single indescribable jewel in eternity. We will discuss about the culture of the famous Zulu tribe of Africa. Zulu is the largest ethnic group of Africa. It has a population of an estimated 10-11 million people, living mainly in the province of Kwazulu-Natal, South Africa. Their language is ‘isiZulu’. It is ‘Bantu language’, more specifically part of the ‘Nguni’ subgroup. Their importance is revealed by the fact that the Zulu Kingdom played a major role in South African History during the 19th and 20th centuries. At one time, Zulu people were classified as the third-class citizens and suffered from state sanctioned discrimination, now they are the most numerous ethnic group among the African tribes and share equal rights among all the other citizens. The Zulu are descendents from a chief from the Congo area. They migrated south in the 16th century, picking up many of the traditions of the San, who also inhabited this South African area. During the 17th and 18th centuries, as a result of the treaties made by many of their most powerful chiefs, the control of the Zulu villages was given to the British. As Zulu had a strong village government systems, so this created much of the conflict and they fought against the British, but could not win because of their small strength. Till 1879, much of the Zulu area was given under the British, but still, the Zulu as a whole decided not to be under British rule, so as a result, war erupted between the British and Zulu. Although the result was in favor of Zulu, as they won the war, but within six months, they were conquered by the British, who exiled the Zulu Kings and divided up the Zulu kingdom. In 1906, another Zulu uprising was lead, continuing their try

Evolution Essay Example | Topics and Well Written Essays - 250 words - 1

Evolution - Essay Example one has ever seen evolution happen, and that if it were a process in progress, evolution should still be right on course with numerous observable "transitional" forms of evidence. The arguments above are but valid in a sense for evolutionary processes in terms of changes in the genetic makeup across populations deem to have been observed in an array of scientific contexts, that include basic laboratory experiments with fruit flies, scientifically known as Drosophila melanogaster and even bacteria have never produced new types of insects. Chemically induced mutations in such organisms have only resulted in mild changes, which include, in the case of fruit flies, those with oversized to no wings, white or even purple eyes (DeBenedictis 383). The minor changes have never had significant change on the organisms, with the changes limited to variations. Even with such experiments being repeated over and over again since Darwin invented the theory, fruit flies remain fruit flies; not a single experiment has successfully changed the organism to a different species (Franklin

Spirituality,Religion,and Social Work Research Paper

Spirituality,Religion,and Social Work - Research Paper Example The relationship between religion, spirituality and social work, however, is not a recent phenomenon, but in fact has existed historically and share a consistent relationship. Such a positive and co-dependent relationship between religion, spirituality and social work, can be attributed to the Postmodernist society we live in today, where there has been a steady and systematic increase in the introduction of new social work policies, which assimilate religion and spirituality; and where the social workers, are known to have a more positive approach towards the inclusion of religion and spirituality within the spheres of social work. There have been various studies which have documented the effect, introduction, assimilation and impact of religion and spirituality within the domains of social work (Furman, Benson, Canda, & Grimwood, 2005; Sheridan & Amato-Von Hemert, 1999; Sheridan, Bullis, Adcock, Berlin, & Miller, 1992). This paper, discusses the various signifcance of the problem, and the impact of such an inclusion on social work and workers. Definition and Meaning of Terms: Religion and Spirituality These terms are defined in various ways by different authors, and research literature on the subject implies that there is no one clear or specific definition for either of these terms. Hence defining the terms in a precise manner has been a challenging task for the authors, since it encompasses a wide area of subjects and concepts. However for the purpose of this study, a general and commonly used definition is taken into consideration. Spirituality is defined as: "a complex, intrapsychic dimension of human development† (Derezotes, 1995, p.1) â€Å"the relationship of the human person to something or someone who transcends themselves† (Bullis, 1996, p. 2), â€Å"devotion to the immaterial part of humanity and nature† (Barker, 1995, p. 363), â€Å"the human search for purpose and meaning of life experiences† (Sheridan & Amato-von Hemer t, 1999, p. 129), â€Å"a relationship to force greater than oneself† (Netting, Thibault & Ellor, 1990), and â€Å"the essence of the individual† (Carroll, 1997, p. 27), or â€Å"one’s basic nature† (Carroll, 1998, p. 2). Religion on the other hand is defined as: â€Å"the external de?nition of faith† (Joseph, 1988, p. 444), â€Å"a search for the signi?cant in ways related to the sacred† (Pargament, 2002, p. 169), â€Å"an organized set of beliefs and practices of a faith community† (Furman & Chandy, 1994, p. 21), â€Å"believing† (Gotterer, 2001, p. 188), and the â€Å"acceptance of a particular set of beliefs and ethics† (Cascio, 1998, p. 524). Thus, the definitions of spirituality and religion in general, are more or less focused on the general meaning of the terms and the areas it encompasses. There is however a subtle difference between the two, as observed from the literature. The concept of spirituality may also include a special reference to the relationship between individuals, the environment to which they belong, their traditions, customs or heritage or any higher power in which they believe (Canda, 1988; Dudley & Helfgott, 1990; Furman, Benson, Canda, & Grimwood, 2005; Joseph, 1988; Krieglstein, 2006; Hodge & McGraw, 2006). Religion on the other hand, is comparatively a narrow term, albeit more structured with regard to the beliefs, or rules followed by a community or an organization. However, there is a slight difference of opinion among various researchers and practitioners with regard to the difference between the two terms while yet others do not believe in such differences. According to some religion is more focused on communities while spirituality is an individual thing, while yet others question the

Objective and subjecive ( you have the file you can read and see its Essay

Objective and subjecive ( you have the file you can read and see its dont have to be the room at algoma u any room - Essay Example The classroom floor uses white glazed tiles. The classroom is lit by rows of fluorescent lighting. This particular classroom has a more professional feel and design to it. Comprised of 3 rows of semi modular computer tables, each row seats up to 4 persons. The computers are mounted to each table and each student uses a top of the line LCD monitor for class lecture purposes. The seats themselves are modern and ergonomic in design and look so that each student can be seated comfortably during the long stretches of class hours. Most of the class lectures in this modern classroom are done via power point presentation as evidenced by the projection screen hanging in front of the students area. The professor has his own table off to the right side corner of the room. The table houses his own computer and other teaching paraphernalia. Mounted to the back of the teachers desk is the white board where manual drawings and notes may be written down for further reference during the lecture. Off to the left side of the room is another small counter that is used to hold other teaching equipmen t or

Comparative Financial Analysis of Target Corporation and JC Penney Term Paper

Comparative Financial Analysis of Target Corporation and JC Penney - Term Paper Example JC Penney likewise had its beginnings in a small dry goods store in 1902 (JC Penney, 2011). Target operates some 1,750 stores within the United States; JC Penney also operated some 2,000 stores at one time, although some have since then been closed due to the economic crisis. Sources of data Data for this study were sourced from the companies’ respective 10-K reports and annual stockholders’ reports from the years 2005 to 2010,and from thence sourced the needed financial statements (income statement and balance sheet), and their accompanying notes and explanations. The reports and additional data were downloaded from the companies’ official websites. Capital accounts: Market and book values The spreadsheets attached to this report show the six-year comparative balance sheets and income statement as they originally appear; as common size, per cent of assets balance sheet and per cent of sales income statement; and then as ratios to the accounts for 2005, the desig nated base year. Then a spread sheet shows the comparative financial ratios computed for the two companies, indicating liquidity, activity, debt, profitability, and per share ratios. For the capital accounts, the most recent per share valuation figures, which are drawn from the spread sheets, are as follows: Indicator Target JC Penney Earnings per share (EPS) $4.03 $1.64 Book value per share (BVPS) $21.99 $22.94 Market price per share (MPS) $44.09 $29.17 Price to earnings ratio (PER) 10.78 X 17.8 X Price to book value (PBV) 2.0 X 1.27 X Dividends per share $0.92 $0.80 Payout ratio 23 % 50 % Data sources: JC Penney 2010 10-K Report; Target 2010 Annual Report From these figures, it is apparent that the two companies have nearly identical book value per share, but significantly different EPS. Target’s EPS is nearly three times that of JC Penney, and in that sense it is more profitable for the shareholders. This higher profitability makes Target more attractive to investors, so i ts market price is considerably higher (Cooper & Argyris, 1998:505; Lee & Lee, 2006:176; De Pamphilis, 2009:292). Target may have a higher price to book value (PBV) and therefore appears more expensive than JC Penney in this regard, but based on PER Target is still cheaper at only 10 times, compared to JC Penney’s nearly 18 times. Target also gives out a higher cash dividend per share, even though payout ratio is smaller and more earnings are being retained in the company. Fixed and non-current assets The balance sheets show that Target’s assets are more than two times that of JC Penney although they have roughly the same number of outlets. The common-size balance sheets show that Target’s current assets average only 40% of the total assets, while JC Penney’s current assets average 50% of its total assets. This does not necessarily mean that JC Penney is under-invested and holds too much liquidity. The sales figures show that JC Penney is only undertaking one-third the business of Target, therefore it may need a greater proportion of its assets for working capital and to bankroll the inventory turnover. Target appears to be operating more efficiently than JC Penney, devoting a lower proportion of its assets to generate a higher volume of sales. Both companies have a measure of goodwill and intangible assets, although their fair values exceed their carrying value. Deferred tax accounts and tax

Ovulatory cycle effects on tip earnings by lap dancers Essay Example for Free

Ovulatory cycle effects on tip earnings by lap dancers Essay The empirical article â€Å"Ovulatory cycle effects on tip earnings by lap dancers: economic evidence for human estrus†, [Myler, Tybur and Jordan, Evolution and Human Behavior 28 (2007) 375 – 381] examines whether human estrus was really â€Å"lost† during evolution. The estrus refers to estrous (or oestrous) cycle that comprises the recurring physiologic changes induced by reproductive hormones in most of mammalian females with a placental reproductive system. Humans undergo a menstrual cycle instead and it is believed by many theorists that human estrus has been lost during evolution. The authors have used an economic model that analyzes the effects of estrus on tip earnings by lap dancers. Typically males of a mammalian species are more solicitous towards a female of the same species. The hypothesis of existence of human estrus is sought to be proved by higher earnings reported by lap dancers during the productive period corresponding to estrus in other placental mammalian species. Here the logical assumption is that an estrous lap dancer would receive more solicitations for private show increasing her tip earnings during estrus. Design of the experiment involved multiple observations (i. e. , tips per shift) for dancers who were nested within contraception use and crossed with cycle phase. The data gathered was used to analyze effects of cycle phase and contraception use on tip earnings using multilevel modeling. Result of the empirical work confirmed the authors’ prediction that pill using and normally cycling participants would demonstrate a similar difference in tip earnings between the menstrual and luteal phases. Second prediction that cycling participants would demonstrate a larger increase in the fertile phase relative to the other phases than pill-using participants was also confirmed by the findings. Experiment found strong ovulatory cycle effects on tip earnings moderated by whether the participants were normally cycling. This path breaking paper provides the first direct economic evidence for the existence of estrus in contemporary human females. Real consumer spending patterns reveal human preferences more reliably than verbally stated judgments do. This is particularly true for socially stigmatized products such as pornography or sex work. The experiment involved only 18 participants which can be considered a relatively small size for an experiment with such vast conclusions. But the small size was adequately offset by an observation period of three months and a sufficiently large number of shifts for which observations were recorded. Moreover, the tip earnings of lap dancers are a result of changes in behavior pattern of a much larger number of their clients who were influenced by the estrous state of the lap dancer. When women and men interact intimately over the course of several minutes through conversation and body contact, women apparently either â€Å"signal† or â€Å"leak† cues of their fertility status, and these cues influence spending patterns by male consumers. These results argue against the view that human estrus evolved to be lost or hidden from males. Logical next step, despite its difficulties, would be further research to clarify whether women have evolved special adaptations to signal estrus through such cues – or whether the cues are â€Å"leaking† to sexually discriminating men as unselected side effects of cycle physiology.

Preventing Teenagers from Smoking

Preventing Teenagers from Smoking Problem statement It is well documented that tobacco use has caused many smoking related diseases yearly; De Meyrick (2000) reported that almost 20,000 people died each year from smoking related diseases. Smoking has been steadily declining in Australia but there is a need to prevent teenagers from even taking up smoking. According to statistics provided by Quit Victoria (2014), the overall rate of smokers among Australian students aged 12 to 17 was 6.7% in 2011, with 4.1 percent of students within the age bracket of 12 to 15 being current smokers and 12.9 per cent of current smokers being in the age bracket of 16 to 17 years of age. Further, it was reported that the majority of adult smokers adopted the habit as teenagers, with the average age of initiation in 2010 being 16 and these smokers took up the habit seriously after progressing from the experimental stage (Tobacco in Australia 2014). It was also found that 16% of males and 13% of females had become regular smokers by the age of 17 (Tobacco in Australia 2014). A study by Chang et al (2005) also found that tobacco smoking among teenagers has been associated with substance abuse and depression as well as a host of mental health problems in both male and female adolescents. Chang et al (2005) further reported that prevention and early intervention into teenage smoking will not only avert later daily smoking but it can also prevent or mitigate the risk for substance use and psychiatric problems. Considering that smoking has caused many health related problems and has also contributed to other social costs, it becomes crucial to prevent teenagers from even adopting the smoking habit. While there are many anti-smoking campaigns, a specific programme targeting teenagers in Victoria is needed to significantly reduce the statistics of 16% male and 13% female teenage smokers by age 17. Needs Analysis Plan The identified problems and service gaps There was no secondary research on the suburbs most at risk of teenage smoking in Victoria. However, interviews with community health care centres, social workers and schools found that the suburbs of Broadmeadows, Dallas, Coolaroo, Frankston North and Bangholme are most at risk of teenagers adopting the smoking habit. The low socio-economic background of the teenagers and poverty associated and family problems have placed these teenagers at the highest risk of not only adopting the smoking habit but also substance and alcohol abuse. There are high incidences of teenagers presenting themselves with problems associated with substance and alcohol abuse, such as depression and self-harm, at the community health care centres. These findings are typical in other research studies research as well (Johnston Thomas 2008). Local police also reports incidences of teenage brawls and fights as well as an overall higher crime rate in these rough suburbs. It has been found from interviews with local support groups, including schools and community health centres as well as social workers that these teenagers feel displaced and isolated. Due to the shortage of resources, there have not been any specific programmes targeting at these teenagers to address smoking, substance or alcohol abuse. There are programmes by local church groups, schools and community health centres to help the residents of these suburbs. However, these programmes are not properly coordinated and are sporadic and short-lived at best. For this reason, the benefits of any community-based programme to help the teenagers cannot really be realised. Interviews with teenagers in these suburbs found that many of them form friendship with other teenagers in schools. Due to cases of bullying or simply for the need of peer support, children as young as pre-primary form friendship with the older children and teenagers, expecting protection from these ‘gangs’. These children learn their habits and emulate behaviour of the older children of the gangs. Interviews with teenagers found that most consider smoking, substance use and alcohol consumption as a rite of passage that they have grown up and accepted as full member of the gangs. For this reason, some teenagers started smoking and drinking as young as 9 years. The fact that many of the parents are also smokers do not help. The high crime rate in these suburbs is due to the lack of employment for teenagers and the need to support their smoking and alcohol habit. As such, the target audience for the proposed funding is primary school children and high school children livin g in the identified suburbs. The service gaps found are the lack of a sustained programme specifically targeting the children and teenagers in the suburbs of Broadmeadows, Dallas, Coolaroo, Frankston North and Bangholme against taking up smoking as well as support programmes for teenagers to quit smoking. While there are attempts in reaching out to our target market in reducing or preventing smoking by various community groups, there is no concerted effort in pooling the efforts of the community support groups through any programme to address the issues that contribute to early adoption of smoking in these communities. This is due to the absence of a person or community group that is solely responsible for such a programme and the lack of funding. After the funding has been proven successful with the proposed interventions, this can be considered for other suburbs in Melbourne and Victoria in the future. Proposed interventions/solutions It is proposed that a Quit Teenage Smoking Project be the responsibility of Quit Smoking Victoria with a dedicated trained personnel (probably a nurse) and two other full-time staff members in a team to oversee the project. A multi-pronged approach with several partners is needed to address teenage smoking in the identified suburbs. Li Powdthavee (2014) reported from their study that people who stay longer in schools tend to be at a lower risk of taking up the smoking habit. For this reason, it is vital to include the schools as an important partner in this project. It is also crucial to include community health care centres as an important partner in this project, for the simple reason that they are the health authority that can discuss health issues with the teenagers who present themselves at these centres for health related issues. Churches and community groups are also critical partners in this project due to their outreach programs and their network in the community to help th ese teenagers. It is also vital to include businesses’ participation as these businesses can offer casual employment to keep the teenagers off the street where they learn how to smoke. The extra money earned can be useful to teenagers to feed themselves and they also learn a skill and feel respected. Businesses can also be involved through some corporate sponsorship. The multi-pronged approach requires the teenagers to be segregated into two different target groups – the non-smokers and the smokers. The objective for the non-smokers is to prevent them from smoking while the immediate objective for the smokers is to reduce smoking. The interventions are discussed as follows – Conclusion The Quit Teenage Smoking Project/Campaign is a proposed project that needs funding by the Victorian Department of Health to prevent teenagers from taking up smoking. Due to the limited funds available, it is proposed that this campaign be carried out in the poorest suburbs of Victoria. The campaign is a multi-pronged approach that engages not only the community health centres in these suburbs but also schools, churches and community groups as well as businesses because smoking is more than a health issue but also a social and emotional one. The main reason why teenagers take up smoking is because they feel that it is a rite of passage and they want to be accepted in their peer groups. Hence, it is important that these teenagers are occupied with better things than getting into trouble and taking up smoking, which can also lead to alcohol and substance abuse. It is proposed that schools be responsible for keeping the students engaged with several proposed programmes while the churches and community groups keep the students occupied with interesting activities so that these teenagers find meaning in their lives with other activities than getting into trouble and smoking. Businesses can actively recruit teenagers to work for them after school and businesses can also provide sponsorship, such as free meals in schools so that students have incentives to go to school. Of course, the community health centres help by providing medical and emotional counselling support. In order to ensure that the campaign is a success, three monthly review of objectives and measurement of goals are important so that adjustment can be made to the campaign to achieve the best results. References Chang, G., Sherritt, L., Knight, J. R. (2005). Adolescent cigarette smoking and mental health symptoms.Journal of Adolescent Health,36(6), 517-522. De Meyrick, J. (2010). Tobacco smokings changing trajectory in Australia.Journal of Business Research,63(2), 161-165. Johnston, V., Thomas, D. P. (2008). Smoking behaviours in a remote Australian Indigenous community: the influence of family and other factors.Social science medicine,67(11), 1708-1716. Li, J., Powdthavee, N. (2014). Does More Education Lead to Better Health Habits? Evidence from the School Reforms in Australia.Social Science Medicine. Quit Victoria Resource Media Centre 2014 http://www.quit.org.au/resource-centre/fact-sheets/smoking-rates Tobacco in Australia 2014, Cancer Council, http://www.quit.org.au/news/

Stability Testing of Nifedeipine

Stability Testing of Nifedeipine Syed Masood Hassan Akbari Practical 2 Stability study of Nifedipine INTRODUCTION Nifedipine is considered as a prototype compound of the dihydropyridine class of calcium channel antagonists. Nifedipine is a selective arterial dilator, and also is used in the treatment of hypertension, angina and cardiovascular disorders. The drawback associated with nifedipine is that it can undergo photo degradation thus escalating in loss of pharmacological activity. This process involves the reduction of the aromatic nitro group to nitroso group or the oxidation of the dihydropyridine ring to a pyridine ring. Nifedipine synthesizers make use of light resistant coating to reduce their photo degradation. It has been found out that due to poor storage conditions the clinical efficacy of nifedipine can drop drastically. In order to fix this a selection of ingredients within the dosage form can be altered or enhanced in order to minimise photosensitivity. Ion-exchange beads are solid and suitably are high molecular weight polyelectrolytes that can easily exchange their mobile ions of equal charge with neighbouring medium reversibly. The ion-exchange bead can form a complex with nifedipine and its utility used to embrace drug in light natures. Instability of the drug product may lead to a reduction in the bioavailability of the drug. It is also highly important that the patients do receive their uniform does of the drug throughout the whole of the shelf life of the product. This experiment goes through the photodecomposition kinetics of nifedipine at zero-order when the reaction commences. As the reaction proceeds further to 50% the kinetics of the reaction changes to first-order. Figure 1: Represents nifedipine degradation at the two different wavelengths shown above. This experiment consisted of 3 main components: Determining the stability of nifedipine using HPLC at various time intervals. Estimating the half-life for the disappearing drug. Examining the relative stability of the drug as powder and in solution. EXPERIMENTAL For HPLC 20mg of nifedipine was weighed out and placed in a 100ml volumetric flask using the mobile phase to top up the flask. The resulting solutions colouration was noted and transferred to a beaker and covered with paraffin. A small insertion was made to take up 2ml of the solution into an injection using a 0.2 µm filter. The time was noted and the sample was loaded and run immediately and the beaker was covered with paraffin and placed on a ledge where sunlight was present and after every 15 min intervals the sample was injected into the apparatus and it was run. After each run was carried out the peak area for each of the runs were recorded. For stability in solid form 100mg of the solid sample of nifedipine was weighed out in a weighing boat and spread out evenly and placed on a window ledge with proper Irish sunlight for a duration of 2 hours. The appearance was noted before and after the time lapsed. The solid sample was then homogenised and 20mg was taken and placed in a 100ml volumetric flask and made up to the mark with the mobile phase. Straight away 2ml solution was taken and placed on a 0.2 µm filter and was ready for injection. The peak area of the solid sample was recorded in the report. RESULTS CONCLUSIONS Determination of the stability of nifedipine solid and liquid samples with sunlight. Table 1: Shows the nifedipine run time with 15 minute intervals, the solid form and a UV sample. The illustrations below show the HPLC peaks at various time intervals with their retention times, peak area and heights. Figure 2: Depicts nifedipine at T0. Figure 3: Depicts nifedipine at T20. Figure 4: Depicts nifedipine at T35. Figure 5: Depicts nifedipine at T50. Figure 6: Depicts nifedipine at T65. Figure 7: Depicts nifedipine at T80. Figure 8: Depicts nifedipine at T95. Figure 9: Represents the peak area plotted against time of nifedipine degradation taken at 15 minute intervals. After carrying out the experiment it can be said looking at the data that the reaction kinetics are of zero order at least from T0-T80. At T95 it is seen that the peak gets a bit broad it can show that a new peak is starting to form, it the experiment had continued for at least 45 minutes more then it could have been the start of the first order reaction kinetics. Therefore it can be deduced that according to the data attained the reaction kinetics are still at zero order during data acquisition. From the graph using the equation: y = a + bx b = slope = -12046.1 +/- 841.833 The half-life of nifedipine was found using the equation: As we were dealing with zero order kinetics so, r = k Using, t1/2 = In(2)/k t1/2 = 0.693/0.988 t1/2 = 0.701 According to the data gathered it is seen that the solid sample of nifedipine resembles to the first T0 liquid sample. By this observation a person can say that the solid state sample did not show any signs of degradation after the 2 hour window. The colour of the liquid samples were changing from yellow at T0 to faint yellow at T80. On the other hand for the solid sample from the light yellow powder after the 2 hour window a layer of dark yellow powder was seen and the powder was mixed around and it was seen the underlying solid particles still retained the same colour of light yellow. According to the UV data at T0 and Ɔºmax of 334 it generated an absorbance of 0.604. Whereas for the T100 with a Ɔºmax of 279 generated an absorbance of 1.064. QUESTIONS Comment on the relative photostability of solid and solution nifedipine in daylight. The solid sample of nifedipine after being expose to 2 hours of Irish sunlight visual observation showed a darker colour change from light yellow to a darker but when the powder was mixed the underlying layer was of the same light colouration as it started with. And after the 2 hours window the HPLC result showed no degradation at all. This could be due to the practical being carried out in doors and the lack of the photons getting to the solid sample. On the other hand in the liquid sample things were not much better from a yellow solution starting at T0 – T80 there was no colour change but after performing the next HPLC the colour had gone faint yellow. If the apparatus would have been given 45 minute more the results attained would be of first order kinetics. As it stands it is zero order kinetics. What type of reaction is the nifedipine decomposition? Reduction What other decomposition reactions do you think nifedipine might undergo? Oxidation What are the implications of your observations for the proper handling and storage of nifedipine? Manufacturers of nifedipine products use light resistant coating or packing to minimize their photodegradation. Long term exposure to sunlight or artificial light may also occur if nifedipine formulations are inappropriately stored by patients. Poor storage conditions may potentially decrease clinical efficacy of nifedipine. What validation do you think might be important in the type of analysis you performed today? â€Å"Validation of an analytical method is the process that establishes by laboratory studies, that the performance characteristics of the method meet the requirements for the intended analytical applications.† The typical analytical characteristics used in method validation vary but the relevant one for this experiment is stability, system suitability and system sensitivity. â€Å"Prepared sample/ standard stability is defined as the ability of the analyte to remain stable in the diluent at the test concentration specified in the analytical method.† System suitability testing is an integral part of many analytical procedures. The tests are based on the concept that the samples to be analysed constitute an integral system that can be evaluated as such. System suitability is determined by various methods. Any one or a combination of the following may be written into the method as necessary for using the method for routine post validation: Resolution ensures that closely eluting compounds are resolved from each other and establishes the resolving power of the system. It contains as close as is possible to a complete sample matrix. Finally capacity factor is a measure of the time the solute spends in the stationary phase relative to the time it spends in the mobile phase.

Graduation Speech: God Has a Plan for You -- Graduation Speech, Commen

In "Surprised By Joy," C.S. Lewis tells of a mistake that he had observed regarding joy or what he calls "thrills." Lewis realized that what he had first thought to be joy, was actually not joy at all because it began to fade away. He had assumed that he was seeking after the "thrill" itself. He says, "And there lies the deadly error. Only when your whole attention and desire are fixed on something else ... does the 'thrill' arise. It is a by-product. Its very existence presupposes that you desire not it but something other and outer." He realized that when he focused his attention on obtaining the "thrill" of joy, that he was actually focused on himself. True joy is not experienced when one desires joy itself, but when one has his eyes on something else. As believers, the "other and outer" that we have the opportunity to look to is God! God draws us to Himself, our soul responds to Him and in return, He fills our soul with joy. That is portrayed in the words of the Psalmist who says in Psalm 43:3-4, "O send our Your light and Your truth, Let them lead me; Let them bring me t...